Phenotype Image Detail

Image

Caption

Reduction of damage to mitochondria and contractile apparatus. Transmission electron microscopy of hearts from wild type (a) Des^tm1Cap/Des^tm1Cap (b) and Des^tm1Cap/Des^tm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap (c) mice. Most sections from double mutant hearts (c) appear very similar to wild type sections (a), in contrast to Des^tm1Cap/Des^tm1Cap sections that display typical mitochondrial swelling and rupture and broken contractile apparatus (b). Scale bar: 5um

Copyright

This image is from Weisleder N, Proc Natl Acad Sci U S A 2004 Jan 20;101(3):769-74. Copyright 2004 National Academy of Sciences, U.S.A. J:88267

Associated Alleles

Symbol	Name
Des^tm1Cap	desmin; targeted mutation 1, Yassemi Capetanaki
Tg(Bcl2)BCap	transgene insertion B, Yassemi Capetanaki

Associated Genotypes

Allelic Composition	Genetic Background
Des^tm1Cap/Des^tm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap	involves: 129S7/SvEvBrd * C57BL/6
Des^tm1Cap/Des^tm1Cap	involves: 129S7/SvEvBrd