Phenotype Image Detail

Image

Caption

(A) Newborn forelimb skeletons (blue, cartilage; red, bone). The humerus in the Shox2^tm1Ddu/Shox2^tm1.1Ddu Tg(Prrx1-cre)1Cjt forelimb is virtually absent except for a small ossification center (arrow), which is located on the anterior/dorsal surface of the cartilage and does not span the axis of the limb. The rest of the limb is relatively normal, except for a slight broadening of the distal scapula (sc). r, radius; u, ulna; a, autopod. (B) Hindlimbs of newborn mice. The femur (f) in the mutant is represented only by a small cartilaginous extension (arrow) of the pelvic girdle (pg). The tibia (t) and fibula (fi) are also noticeably shorter in the mutant, whereas the autopod (paw) is normal. The ilium (triangle) is also small in the mutant and contains an abnormal asymmetric ossification center similar to that of the humerus in a. (C) Adult forelimb skeletons with bones stained with Alizarin red. The extremely small humerus (h) of the mutant is ossified and fused to the scapula (sc). (D) Adult hindlimbs. The tiny mutant femur (f) is now ossified and fused to the pelvic girdle. The tibia (t) is short and bowed, and the fibula contains an ectopic ossification center (filled triangle). As in newborns, the ilium (triangle) is significantly shorter in the mutant. In contrast, the mutant autopod is of similar size and morphology to that of wild type mice. Scale bar: A & B, 1mm; C & D, 5mm

Copyright

This image is from Cobb J, Proc Natl Acad Sci U S A 2006 Mar 21;103(12):4511-5. Copyright 2006 National Academy of Sciences, U.S.A. J:107668

Associated Alleles

Symbol	Name
Shox2^tm1.1Ddu	SHOX homeobox 2; targeted mutation 1.1, Denis Duboule
Shox2^tm1Ddu	SHOX homeobox 2; targeted mutation 1, Denis Duboule
Tg(Prrx1-cre)1Cjt	transgene insertion 1, Clifford J Tabin

Associated Genotypes

Allelic Composition	Genetic Background
Shox2^tm1Ddu/Shox2^tm1.1Ddu Tg(Prrx1-cre)1Cjt/0	involves: 129S2/SvPas * C57BL/6J * SJL/J