Phenotype Image Detail

Image

Caption

Gpnmb^R150X/Gpnmb^R150X irides at (F) 4 months, (G) 9 months and (H) 20 months. From 1-5 months, mutant mouse eyes were indistinguishable from wild type eyes. Near 6 months, mutant mouse eyes developed a pronounced peripupillary swelling accompanied by a pronounced accumulation of clump cells on the iris surface. These swellings remained prominent to the oldest ages examined. The iris surface maintained an overall normal morphology during the first year, after which time it became increasingly atrophic, and accumulations of dispersed pigment were visible on the lens and cornea.

Copyright

This image is from Anderson MG, BMC Biol 2006;4():20, an open-access article, licensee BioMed Central Ltd. J:128215

Associated Alleles

Symbol	Name
Gpnmb^R150X	glycoprotein (transmembrane) nmb; iris pigment dispersion

Associated Genotypes

Allelic Composition	Genetic Background
Gpnmb^R150X/Gpnmb^R150X	B6.D2-Gpnmb^R150X