Phenotype Image Detail

Image

Caption

Cohorts of Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b mice were aged and analyzed by slit-lamp examination; representative eyes of indicated ages are shown. Each row contains three images of the same eye. The left column shows a broad-beam illumination. The middle column shows transillumination defects. The right column shows the relative dimensions of the anterior chamber. A-C: Until 5 months, double homozygous mutant mouse eyes were indistinguishable from wild type eyes, with a complex iris morphology, not transillumination, and anterior chambers of normal dimension with a closely juxtaposed cornea and iris. D-F: By 6 months, all mutant mouse eyes exhibit a clear phenotype characterized by slight swelling of peripupillary tissue. G-I: In 9 month old eyes, the peripupillary region becomes notably atrophic, transillumination is obvious, and dispersed pigment is present on both the lens and cornea. Beyond this age, a steadily worsening course ensues, which at (J-L) 12 months, (M-O) 14 months, and (P-R) 18 months is characterized by increasing degrees of iris atrophy that include full-thickness iris holes, profound transillumination, pigment dispersion and frequent pigment accumulation on the lens and cornea, and changes to the dimensions of the anterior chamber.

Copyright

This image is from Anderson MG, BMC Biol 2006;4():20, an open-access article, licensee BioMed Central Ltd. J:128215

Associated Alleles

Symbol	Name
Gpnmb^R150X	glycoprotein (transmembrane) nmb; iris pigment dispersion
Tyrp1^b	tyrosinase-related protein 1; brown

Associated Genotypes

Allelic Composition	Genetic Background
Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b	B6.D2-Tyrp1^b Gpnmb^R150X