Phenotype Image Detail

Image

Caption

Panels A and B depict hematoxylin and eosin staining of E16.5 wild type and Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreas, respectively, each at 25x magnification. Hypoplasia of the developing pancreas is already apparent and was consistently present by this stage. Panels C, D and E demonstrate wild type pancreata at E12.5, 14.5 and 16.5, respectively, stained with an antibody specific for the transcriptionally active, dephosphorylated for of beta-catenin. Note that staining is abundant at ED12.5, but is undetectable following the secondary transition at E16.5.

Copyright

This image is from Wells JM, BMC Dev Biol 2007;7():4, an open-access article, licensee BioMed Central Ltd. J:119908

Associated Alleles

Symbol	Name
Ctnnb1^tm4Wbm	catenin beta 1; targeted mutation 4, Walter Birchmeier
Tg(Pdx1-cre)6Tuv	transgene insertion 6, David A Tuveson

Associated Genotypes

Allelic Composition	Genetic Background
Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Tg(Pdx1-cre)6Tuv/0	involves: 129P2/OlaHsd * FVB/N