Phenotype Image Detail

Image

Caption

Panel A shows the size and general morphology of wild type (left) and Dhcr7^tm1Gst/Dhcr7^tm1Gst (right) embryos at E10.5, without significant difference. At P0, the mutant pups are significantly smaller and appear hypoxic (panel B). Panel C shows dorsal views of lungs from mutant (right) and wild type (left) at E13.5 and Panel D those at P0. Cross-sectional examination at the cardiopulmonary level at E20.5 (prior to birth) shows normal lobar septation, but lungs from mutant mice are smaller in size and have less distal sac space (cf. Panels E & F). Original magnification: Panels A & C 2x; Panels B & D, 0.7x; Panels E & F, 2x. Abbreviations: r, right; l, left; b, bronchial; br, bronchiole; e, esophagus; pa, pulmonary artery; ra, right atrium; la, left atrium; rv, right ventricle; lv, left ventricle.

Copyright

This image is from Yu H, BMC Dev Biol 2004 Mar 2;4(1):1, an open-access article, licensee BioMed Central Ltd. J:93296

Associated Alleles

Symbol	Name
Dhcr7^tm1Gst	7-dehydrocholesterol reductase; targeted mutation 1, G S Tint

Associated Genotypes

Allelic Composition	Genetic Background
Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7^tm1Gst