Phenotype Image Detail

Image

Caption

Healing of 25mm oblong skin wounds (A) and histology of 6mm circular skin wounds (B) in wild type and Sparc^tm1Hwe/Sparc^tm1Hwe mice. In (A) upper panel: an example of the progress of repair processes at the indicated times (days) shown. S, scab; W, open wound field. In (A) lower panel: percent of wild type and mutant mice (6 in each group) with healed wounds, defined as loss of the wound scabs and complete covering of the wounds with epidermis, is plotted versus days after excision. Panel (B) illustrates histologic appearance of 6mm wounds in a wild type and mutant mouse 4 days after surgery. Granulation (G) tissue formation is more extensive in the wild type mouse than in the mutant mouse. Arrows indicate reepithelialized wound edge. Reepithelialization appears to be as efficient in mutant mice as in wild type mice. S, scab, P, panniculus carnosus. Hematoxylin and eosin staining. Scale bar, 210um.

Copyright

This image is from Basu A, BMC Cell Biol 2001;2():15, an open-access article, licensee BioMed Central Ltd. J:102567

Associated Alleles

Symbol	Name
Sparc^tm1Hwe	secreted acidic cysteine rich glycoprotein; targeted mutation 1, Chin Chen Howe

Associated Genotypes

Allelic Composition	Genetic Background
Sparc^tm1Hwe/Sparc^tm1Hwe	involves: 129S/SvEv * C57BL/6J