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Phenotype Image Detail
Image
Caption Tumor located in the stomach of a Mbd4tm1Wed/Mbd4tm1Wed Apctm1Rak/Apc+ mouse with characteristic features of microadenoma, composed of a cluster of neoplastic glands of varying sizes and shapes. The tumor cells in the glands are crowded and show enlarged nuclei and hyperchromatic staining. Hematoxylin/eosin x200.
Copyright This image is from Wong E, Proc Natl Acad Sci U S A 2002 Nov 12;99(23):14937-42. Copyright 2002 National Academy of Sciences, U.S.A. J:80319
Associated
Alleles
Symbol Name
Apctm1Rak APC, WNT signaling pathway regulator; targeted mutation 1, Raju Kucherlapati
Mbd4tm1Wed methyl-CpG binding domain protein 4; targeted mutation 1, Winfried Edelmann
Associated
Genotypes
Allelic Composition Genetic Background
Apctm1Rak/Apc+
Mbd4tm1Wed/Mbd4tm1Wed 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory