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Phenotype Image Detail
Image
Caption Nissl staining of control (Gbatm2Karl/Gba+ Tg(KRT14-cre)8Brn/?) mice (A-D) and Gba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? mice (E-F). Loss of neurons was observed in red nucleus (E), pons (F) medulla (G) and cerebellum (H). Purkinje neurons (indicated by arrows in D and H) are reduced in numbers and appear shrunken. All mice were about 2 weeks old at analysis. Scale bar in A & E, 30um; B and F, 60um; C and G, 50um; D and H, 40um.
Copyright This image is from Enquist IB, Proc Natl Acad Sci U S A 2007 Oct 30;104(44):17483-8. Copyright 2007 National Academy of Sciences, U.S.A. J:127108
Associated
Alleles
Symbol Name
Gba1tm2Karl glucosylceramidase beta 1; targeted mutation 2, Stefan Karlsson
Tg(KRT14-cre)8Brn transgene insertion 8, Anton Berns
Associated
Genotypes
Allelic Composition Genetic Background
Gba1tm2Karl/Gba1tm2Karl
Tg(KRT14-cre)8Brn/? 		involves: 129S1/Sv * 129X1/SvJ * FVB/N
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory