Phenotype Image Detail

Image

Caption

A & B: E9.5 Ptprb^tm1Gdy/Ptprb^tm1Gdy yolk sacs (B) can be clearly distinguished from control (Ptprb^tm1Gdy/Ptprb⁺) littermates (A), because of a wrinkled appearance and a lack of visible vessels, which can be seen in the yolk sacs from control littermates (A, red arrows). C & D: Whole-mount PECAM-1 staining at E9.5 confirms the lack of normal vessels in mutant yolk sacs (D) compared with controls (C). The endoderm and mesoderm layers in mutant yolk sacs are barely connected (D, blue arrows), and the entire surface is lined with PECAM-1-positive endothelial cells (ECs, red arrows). E & F: PECAM-1/hematoxylin/eosin staining of E9.5 yolk sac cross sections. In control yolk sacs (E), the vessels are well formed (red arrows). In mutant yolk sacs (F), the vessels are so large (red arrows) that the endoderm and mesoderm layers are only sparsely connected (blue arrow).

Copyright

This image is from Dominguez MG, Proc Natl Acad Sci U S A 2007 Feb 27;104(9):3243-8. Copyright 2007 National Academy of Sciences, U.S.A. J:125903

Associated Alleles

Symbol	Name
Ptprb^tm1Gdy	protein tyrosine phosphatase receptor type B; targeted mutation 1, George D Yancopoulos

Associated Genotypes

Allelic Composition	Genetic Background
Ptprb^tm1Gdy/Ptprb^tm1Gdy	involves: 129 * C57BL/6