Phenotype Image Detail

Image

Caption

A & B: Dissected E9.5 embryos. Ptprb^tm1Gdy/Ptprb^tm1Gdy embryos have pericardial edema (blue arrow) (B). Although mutant embryos are small and developmentally delayed compared with control (Ptprb^tm1Gdy/Ptprb⁺) littermates (A), their hearts tend to have similar lengths (dotted line is the same length in A and B). C & D: Whole-mount PECAM-1 staining of E9.5 h earts. The pattern of the control heart (C) shows distinct ventricle and atrium staining (blue arrows), as well as staining in the connecting atrioventricular canal (black arrow). In the mutant heart (D), there is only staining in the ventrticle (blue arrow) and atrioventricular canal (black arrow), but not in the atrium (dotted circle).

Copyright

This image is from Dominguez MG, Proc Natl Acad Sci U S A 2007 Feb 27;104(9):3243-8. Copyright 2007 National Academy of Sciences, U.S.A. J:125903

Associated Alleles

Symbol	Name
Ptprb^tm1Gdy	protein tyrosine phosphatase receptor type B; targeted mutation 1, George D Yancopoulos

Associated Genotypes

Allelic Composition	Genetic Background
Ptprb^tm1Gdy/Ptprb^tm1Gdy	involves: 129 * C57BL/6