Phenotype Image Detail

Image

Caption

A-F: Appearance of control (CT) and Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (Rxralpha beta ^ep-/-) mice at weeks 2 and 24 as indicated. The white arrowhead in E points to reddening and thickening of a mutant ear at week 2, to be compared with its normal appearance in a CT mouse (D). Black arrows in C and F point to skin lesions seen at week 24 on the back and the ears, and on the face and the neck, respectively. G-L: Hematoxylin and eosin stained sections of ear (G-I) and dorsal skin (J-L) of CT and mutant mice at week 2 and 12. White arrows point to dermal/epidermal junction. Yellow arrows point to blood vessels. hf, hair follicle; u, urtriculi. Scale bar, 50um.

Copyright

This image is from Li M, Proc Natl Acad Sci U S A 2005 Oct 11;102(41):14795-800. Copyright 2005 National Academy of Sciences, U.S.A. J:102470

Associated Alleles

Symbol	Name
Rxra^tm4Ipc	retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
Rxrb^tm1Pcn	retinoid X receptor beta; targeted mutation 1, Pierre Chambon
Tg(KRT14-cre/ERT2)1Ipc	transgene insertion 1, I Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas