Phenotype Image Detail

Image

Caption

A-F: Immunohistochemical (IHC) staining was performed on ear sections from control (CT) and Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (MT) mice at week 8, with antibodies against CD4 (A and B), CD11c (C and D), and MHCII (E and F). Red color corresponds to staining of antibodies, whereas blue corresponds to DAPI staining of nuclei. White arrows point to dermal/epidermal junction. Scale bar 50um. G-H: Luna's staining. Eosinophils (pointed by red arrows in H, Inset) display intracytoplasmic red staining. I-J: Electron microscopic (EM) analyses. Eosinophils with crystal-like rectangular inclusions are pointed by blcak arrows and shown enlarged in J, inset. K-L: Toluidin blue-stained sections. In each panel, the black arrow points to one of the mast cells showing intensive blue color. Scale bars, G, H, K and L, 50um; I and J, 2um.

Copyright

This image is from Li M, Proc Natl Acad Sci U S A 2005 Oct 11;102(41):14795-800. Copyright 2005 National Academy of Sciences, U.S.A. J:102470

Associated Alleles

Symbol	Name
Rxra^tm4Ipc	retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
Rxrb^tm1Pcn	retinoid X receptor beta; targeted mutation 1, Pierre Chambon
Tg(KRT14-cre/ERT2)1Ipc	transgene insertion 1, I Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas