Phenotype Image Detail

Image

Caption

A-D: Defects in the great vessels in E13.5 mutant embryos. In the transverse section of the wild type embryo, the pulmonary trunk communicates with the descending aorta via the ductus arteriosus (A). Mrtfb^tm1Eno/Mrtfb^tm1Eno embryos display hypoplastic pulmonary trunk (arrowhead) and no ductus arteriosus (B), persistent right-sided ductus arteriosus (C), and interrupted aortic arch (D). Note the abnormal shape and position of the descending aorta where the ductus arteriosus joins (*). a, aorta; at, atrium; d, ductus arteriosus; rv, right ventricle. E-H: Schematic diagrams of aortic arch defects seen in A-D. Dotted lines represent normal regression. Black areas depict abnormal regression, where blue areas indicate abnormal persistence. E: Patterning of the branchial arch arteries in the wild type embryo with normal regression of the right sixth artery (-R6). F: Absence of the ductus arteriosus resulting from abnormal regression of the left sixth artery (-L6). G: Persistent right-sided ductus caused by abnormal regression of the left sixth artery (-L6) and abnormal persistence of the right sixth artery (+R6). H: Interrupted aortic arch and loss of both carotid arteries, due to abnormal regression of the left fourth (-L4) and both right and left third arteries (-R3, -L3). R3, R4 and R6, right arch arteries 3, 4 and 6 respectively. L3, L4 and L6, left aortic arch arteries, respectively.

Copyright

This image is from Oh J, Proc Natl Acad Sci U S A 2005 Oct 18;102(42):15122-7. Copyright 2005 National Academy of Sciences, U.S.A. J:102475

Associated Alleles

Symbol	Name
Mrtfb^tm1Eno	myocardin related transcription factor B; targeted mutation 1, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Mrtfb^tm1Eno/Mrtfb^tm1Eno	involves: 129S/SvEv * C57BL/6