Phenotype Image Detail

Image

Caption

A-C: Appearance of control (CT) (A), Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (Rxralpha beta ^ep-/-) (B), and Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (RXRalpha beta^epaf2o)(C) mice at week 5. Close views of the ears are shown in Insets. Black arrows in B and C point to regions with hair loss, and white arrowhead in B Inset points to the red and swollen ear. D-F: Hematoxylin and eosin staining of ear sections of CT (D), Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (E), and Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (F) at week 5. White arrows point to dermal-epidermal junction. hf, hair follicle; u, utriculi. Scale bar 50um.

Copyright

This image is from Li M, Proc Natl Acad Sci U S A 2005 Oct 11;102(41):14795-800. Copyright 2005 National Academy of Sciences, U.S.A. J:102470

Associated Alleles

Symbol	Name
Rxra^tm1Ipc	retinoid X receptor alpha; targeted mutation 1, Pierre Chambon
Rxra^tm4Ipc	retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
Rxrb^tm1Mma	retinoid X receptor beta; targeted mutation 1, Manuel Mark
Rxrb^tm1Pcn	retinoid X receptor beta; targeted mutation 1, Pierre Chambon
Tg(KRT14-cre/ERT2)1Ipc	transgene insertion 1, I Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas
Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas