Phenotype Image Detail

Image

Caption

A: IgE and IgG levels in sera of nine controls (CT) and nine Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 (MT) mice at week 12. The average values are indicated by short lines. B: Lymph node (LN) hyperplasia and splenomegaly in MT mice. Cervical LNs and spleens from a CT and two MT (MT1 and MT2) mice are shown at week 20. The relative weights of cervical LN and spleen body weights (BW) from CT and MT mice at week 0-20 are presented. C: Luna's staining of cervical LN, spleen and liver sections (as indicated) at week 12. The white arrow points to one of the many eosinophils (stained red in cytoplasn and blue nucleus). The black arrowhead points to erythrocytes (stained red in cytoplasm). V, vein. Scale bar, 25um.

Copyright

This image is from Li M, Proc Natl Acad Sci U S A 2005 Oct 11;102(41):14795-800. Copyright 2005 National Academy of Sciences, U.S.A. J:102470

Associated Alleles

Symbol	Name
Rxra^tm4Ipc	retinoid X receptor alpha; targeted mutation 4, Pierre Chambon
Rxrb^tm1Pcn	retinoid X receptor beta; targeted mutation 1, Pierre Chambon
Tg(KRT14-cre/ERT2)1Ipc	transgene insertion 1, I Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas