Phenotype Image Detail

Image

Caption

A: Percentage of fragmented unfertilized oocytes collected in the ampullae of females at different ages after exogenous hormonal stimulation. Total number of oocytes analyzed is indicated above the columns (open columns, wild type; black columns Gpr3^tm1Cled/Gpr3^tm1Cled, oocytes). Whereas both genotypes produced progressively more fragmented oocytes with age (P<0.001), at all ages, homozygous mutant mice produced more fragmented oocytes than wild type (P<0.001). B: Non fertilized mutant oocytes observed in light microscopy by using Nomarski optics at time of harvest in the ampullae of superovulated females. Normally shaped unfertilized oocytes with or without polar body, fragmented oocytes, and oocytes exhibiting cytoplasmic condensation are observed. Scale Bar, 40um. C: Histology sections of mutant fragmented oocytes observed in follicles (A and B) and oviducts (C) after stimulation by human chorionic gonadotropin. Scale Bar, A-C 20um; B, 10um.

Copyright

This image is from Ledent C, Proc Natl Acad Sci U S A 2005 Jun 21;102(25):8922-6. Copyright 2005 National Academy of Sciences, U.S.A. J:105182

Associated Alleles

Symbol	Name
Gpr3^tm1Cled	G-protein coupled receptor 3; targeted mutation 1, Catherine Ledent

Associated Genotypes

Allelic Composition	Genetic Background
Gpr3^tm1Cled/Gpr3^tm1Cled	either: B6.129-Gpr3^tm1Cled or (involves: 129S1/Sv * 129X1/SvJ * CD-1)