Phenotype Image Detail

Image

Caption

Electron micrographs of outer and inner segments from retinae of littermate wild type (A, C and E) and Dnajc5^tm1Sud/Dnajc5^tm1Sud mice (B, D and F) at P28. The outer segment region from the respective mice is shown, whereas E and F focuses on the inner segments. In mutant mice, membrane stacks of the outer segments appeared partly clumped and largely adopted an abnormal shape (asterisks in B, D and F). In some cases, outer segments were found at abnormal positions in the inner segment regions (arrow in F). Furthermore, in the mutant mice, vesicle trafficking in the inner segments appeared to be reduced compared to wild type mice as judged by the number of intracellular membrane profiles and vesicles in the inner segments. OS, outer segments; IS, inner segments; m, mitochondria; G, Golgi apparatus. Scale bars, A-D, 500nm; E and F, 1um.

Copyright

This image is from Schmitz F, Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2926-31. Copyright 2006 National Academy of Sciences, U.S.A. J:107310

Associated Alleles

Symbol	Name
Dnajc5^tm1Sud	DnaJ heat shock protein family (Hsp40) member C5; targeted mutation 1, Thomas C Sudhof

Associated Genotypes

Allelic Composition	Genetic Background
Dnajc5^tm1Sud/Dnajc5^tm1Sud	involves: 129S6/SvEvTac