Phenotype Image Detail

Image

Caption

A: Macroscopic view of the testes at 8 weeks of age from wild type littermates and Prokr1^tm1Api/Prokr1^tm1Api (Pkr1) mice (Left), wild type littermates and Prokr2^tm1Api/Prokr2^tm1Api (Pkr2) (Center), and the ovary and uterus (Right) at 12 weeks of age from wild type, Prokr1, and Prokr2 mutant mice. The male and female reproductive organs are small in the Prokr2 mutant mice. Scale bars, 5mm. B: Hematoxylin and eosin stained sections of wild type and Prokr2 mutant testis at 20 weeks of age. Higher magnification (rectangle) shows normal Leydig cells in the wild type testis (Lower Left), whereas the mutant testis shows small Leydig cells and no spermatid (Lower Right). SPG, spermatogenic cell; SPC, spermatocytes; SPT, spermatid; LC, Leydig cells. Scale bars, Upper, 100um; Lower, 10um. C: Hematoxylin and eosin stained sections of wild type and Prokr2 mutant ovary at 20 weeks of age. A magnified region (rectangle) shows normal antral follicle (arrow) in wild type ovary (Lower Left). A magnified region (rectangle) shows undeveloped follicles (arrows) in Prokr2 mutant ovary (Lower Right). Scale bars, Upper, 200um; Lower, 50um.

Copyright

This image is from Matsumoto S, Proc Natl Acad Sci U S A 2006 Mar 14;103(11):4140-5. Copyright 2006 National Academy of Sciences, U.S.A. J:107587

Associated Alleles

Symbol	Name
Prokr1^tm1Api	prokineticin receptor 1; targeted mutation 1, Shunichiro Matsumoto
Prokr2^tm1Api	prokineticin receptor 2; targeted mutation 1, Shunichiro Matsumoto

Associated Genotypes

Allelic Composition	Genetic Background
Prokr1^tm1Api/Prokr1^tm1Api	involves: C57BL/6 * CBA
Prokr2^tm1Api/Prokr2^tm1Api	involves: C57BL/6 * CBA