Phenotype Image Detail

Image

Caption

Hematoxylin and eosin stained parasagittal sections of the upper nasal region in wild type littermates at E12.5 (A, E and I), Prokr2^tm1Api/Prokr2^tm1Api (Pkr2^-/^-) mice at E12.5 (B, F and J), wild type littermates at E13.5 (C, G and K) and homozygous mutant mice at E13.5 (D, H and L). Note that a sphere-shaped structure was observed at the region between the olfactory pit and forebrain in mutant mice at both E12.5 and E13.5 (arrowhead in B and D). This structure is particularly evident when viewed at higher magnification (arrowhead in F, H, J and L). OP, olfactory pit; F, forebrain. Scale bars, A-D, 200um; E-H, 100um; and I-L, 50um.

Copyright

This image is from Matsumoto S, Proc Natl Acad Sci U S A 2006 Mar 14;103(11):4140-5. Copyright 2006 National Academy of Sciences, U.S.A. J:107587

Associated Alleles

Symbol	Name
Prokr2^tm1Api	prokineticin receptor 2; targeted mutation 1, Shunichiro Matsumoto

Associated Genotypes

Allelic Composition	Genetic Background
Prokr2^tm1Api/Prokr2^tm1Api	involves: C57BL/6 * CBA