Phenotype Image Detail

Image

Caption

E and F: Masson's Trichrome staining of E18.5 ureter corss-sections. Smooth muscle cells (SMCs) are organized into circular muscle in the wild type, but appear disorganized in the Dlg1^tm1Jhm/Dlg1^tm1Jhm (Dlgh1^-/^-) mouse. G and H: Transmission electron micrographs of E18.5 ureter cross-sections. SMCs are spindle-shaped in the wild type (G) but rounded in the mutant (H). I and J: Toluidine blue staining of E18.5 ureter longitudinal sections. SMCs are rounded in the wild type (I) but spindle-shaped in the mutant (J). K and L: Transmission electron micrographs of the E18.5 ureter longitudinal sections. SMCs are rounded in the wild type (K) but spindle-shaped in the mutant (L). These results indicate that in the absence of DLGH1, SMCs that are normally organized into circular muscle are instead oriented longitudinally. sm, smooth muscle. Scale bars: E and F, 50um; G-L, 10um.

Copyright

This image is from Mahoney ZX, Proc Natl Acad Sci U S A 2006 Dec 26;103(52):19872-7. Copyright 2006 National Academy of Sciences, U.S.A. J:118250

Associated Alleles

Symbol	Name
Dlg1^tm1Jhm	discs large MAGUK scaffold protein 1; targeted mutation 1, Jeffrey H Miner

Associated Genotypes

Allelic Composition	Genetic Background
Dlg1^tm1Jhm/Dlg1^tm1Jhm	involves: 129 * C57BL/6J