Phenotype Image Detail

Image

Caption

Semilunar valve (SLV) dysmorphogenesis in Ackr3^tm1.1Fma/Ackr3^tm1.1Fma mice. Adult aortic valve from control (A, C and E) and mutant (B, D and F) mice. Arrows indicate leaflet boundaries. A and B: Supravalvular view. Planes of sections shown in D and F are indicated. C-F: Sections through the valves presented in A and B. (C and D) Safranin O staining; red indicates proteoglycans and glucosaminoglycans. (E and F) Movat pentachrome staining; blue indicates proteoglycans. Neonatal phenotype: (G and H) Dissected control and mutant hearts. Right ventricle (RV) is often dilated in mutant mice. I and J: Hematoxylin and eosin-counterstained sections of control and mutant hearts. Membranous ventricular septal defects (VSD, red arrow) and sometimes overriding aorta can be seen in mutants. Dissected aortic (K-N) and Pulmonary (O-R) valves from control and mutant neonates. Arrows indicate leaflet boundaries. Control aortic (K) and pulmonary (O) valves. (L-M, P-R) Phenotypical alterations in mutant valves ranging from thickening, with occasional fusion of valve leaflets (L and P), to formation of bicuspid valve (M and Q), to obstruction of the valve by an overgrown leaflet (N and R). S-V: Sections through the neonatal aortic (S and T) or pulmonary (U and V) valves of control (S and U) or mutant (T and V) mice. Black arrows point to valve leaflets. AV, aortic valve; PV, pulmonary valve; LV, left ventricle; Ao, aorta.

Copyright

This image is from Sierro F, Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14759-64. Copyright 2007 National Academy of Sciences, U.S.A. J:124878

Associated Alleles

Symbol	Name
Ackr3^tm1.1Fma	atypical chemokine receptor 3; targeted mutation 1.1, Fabienne Mackay

Associated Genotypes

Allelic Composition	Genetic Background
Ackr3^tm1.1Fma/Ackr3^tm1.1Fma	involves: BALB/cJ * C57BL/6