Phenotype Image Detail

Image

Caption

Transmission EM images of renal tubules. Asterisks indicate the lumen of the biliary canal or, in the case of the Xylt2^tm1Meh/Xylt2^tm1Meh mice (D-F), the cystic lumen. A: Control biliary epithelial cells (BECs) lining a biliary tract. Microvilli can be seen in the lumen at the epithelial cell apical membranes. (Scale bar: 2um.) B: Wild type BEC apical and basolateral surfaces. Basolateral junction of plasma membrane is slightly undulated, and the basement membrane (BM) is clearly defined and uniform in thickness (arrows). (Scale bar: 500nm.) C: Control BEC apical and lateral junction of two BECs showing apical microvilli, tight junctions (arrowheads), and normal membranous junction between cells. (Scale bar: 500nm.) D: Cyst-associated BECs showing apical microvilli and secretory vesicles/granules (Sg). (Scale bar: 2um,) E: Basolateral portion of BEC showing the lateral plasma membrane projections (Lp) and discontinous, indistinct, and thickened BM (arrows). Collagen (col) deposition is also observed. (Scale bar: 500nm.) F: Xylt2^tm1Meh/ Xylt2^tm1Meh apical portion of cyst-associated BECs showing normal-appearing tight junctions (arrowheads) and microvilli, but, in contrast to controls, the presence of secretory granules. Scale bar: 500nm.

Copyright

This image is from Condac E, Proc Natl Acad Sci U S A 2007 May 29;104(22):9416-21. Copyright 2007 National Academy of Sciences, U.S.A. J:122291

Associated Alleles

Symbol	Name
Xylt2^tm1Meh	xylosyltransferase II; targeted mutation 1, Myron E Hinsdale

Associated Genotypes

Allelic Composition	Genetic Background
Xylt2^tm1Meh/Xylt2^tm1Meh	involves: 129P2/OlaHsd