Phenotype Image Detail

Image

Caption

Stat3^tm1Flv/Stat3^tm1Flv Tg(Nes-cre)1Kln/0 (KO) mice are twice as heavy as wild type (WT) mice (A) and consume twice as much food (B). Livers of mutant mice are severely enlarged and fatty (C) and accumulated a large amount of fat (fatty liver) (D and E). (**, P<0.001).

Copyright

This image is from Gao Q, Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4661-6. Copyright 2004 National Academy of Sciences, U.S.A. J:89242

Associated Alleles

Symbol	Name
Stat3^tm1Flv	signal transducer and activator of transcription 3; targeted mutation 1, Richard A Flavell
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Stat3^tm1Flv/Stat3^tm1Flv Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL