Phenotype Image Detail

Image

Caption

Hearts from 5 month old Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae mice (mdx:MyoD-/-, right) were compared with age-matched wild type littermates (left). A: Intact hearts of mutant mice appeared significantly larger than hearts from wild type mice. B: Hematoxylin and eosin stained sections of hearts (cut transversely at midventricle) revealed an increased ventricular diameter in mutant mice compared with wild type mice. Although hearts were fixed ex vivo without diastole arrest, the apparent increase in ventricular diameter without concurrent changes in ventricular thickness suggests dilatation. C: Cardiomyocyte hypertrophy and disarray in mutant mouse hearts are observed, which are not present in wild type mice. Magnification: A and B, 2mm; C, x40.

Copyright

This image is from Megeney LA, Proc Natl Acad Sci U S A 1999 Jan 5;96(1):220-5. Copyright 1999 National Academy of Sciences, U.S.A. J:52248

Associated Alleles

Symbol	Name
Dmd^mdx	dystrophin, muscular dystrophy; X linked muscular dystrophy
Myod1^tm1Jae	myogenic differentiation 1; targeted mutation 1, Rudolf Jaenisch

Associated Genotypes

Allelic Composition	Genetic Background
Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae * C57BL/10ScSn