Phenotype Image Detail

Image

Caption

A: Increase in the percentage of anaphases with anaphase bridging in the GI tract of late-generation Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf+/+) mice. Error bars represent mean SE (n = 4-7 for each group). No significant difference between late-generation Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf+/+) and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf-/-) mice (P = 0.1306). Twenty-five anaphases were counted per sample. B: Representative examples of the degenerative phenotype seen in 12- to 13-week old G4 Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf+/+) and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf-/-) mice. C: Increase in apoptotic bodies in the crypts of the GI tract in late-generation Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf+/+) and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf-/-) mice. No significant differences between the number of apoptotic bodies between the different mutants within the same generation (P=0.9084). Error bars represent mean SE (n = 4-7 for each group). D: p53 induction in late-generation Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf+/+) and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf-/-) intestinal crypts. E: Testes weights (left) and histological sections (right) of early and late-generation Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf+/+) and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp (Ink4a/Arf-/-) mutant mice. Loss of Cdkn2a does not rescue germ cell depletion in late-generation Terc^tm1Rdp/Terc^tm1Rdp testes. Inset shows depletion of spermatogonia in late-generation Terc^tm1Rdp/Terc^tm1Rdp testes.

Copyright

This image is from Khoo CM, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3931-6. Copyright 2007 National Academy of Sciences, U.S.A. J:120065

Associated Alleles

Symbol	Name
Cdkn2a^tm1Rdp	cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho
Terc^tm1Rdp	telomerase RNA component; targeted mutation 1, Ronald DePinho

Associated Genotypes

Allelic Composition	Genetic Background
Terc^tm1Rdp/Terc^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL
Terc^tm1Rdp/Terc^tm1Rdp	involves: FVB/N