Phenotype Image Detail

Image

Caption

Comparison of postnatal middle ear cavitation in wild type (+/+, left) and Eya4^tm1Jse/Eya4^tm1Jse mice (-/-, right). A: Six day old mice (n=6, each genotype) had no middle ear effusions. Mesenchymal cells (black arrows) are found in the middle ear cavity, but the middle ear space (red arrows) is visible. Co, cochlea. Scale bars: 200um. B: At days 11 and 12 ( n=3 mice of each genotype), mesenchymal cells (black arrows) have largely disappeared from the middle ear cavity of wild type mice, but a few cells remain around the ossicles. M, malleus. Many more mesenchymal cells and collagen (asterisks), a by-product of mesenchyme regression, are present in the MECs of mutant mice than in wild type mice. See magnified inset (scale bars: 200um) showing mucoperiosteum and mesenchyme regression. The marked inward bulging of tympanic membrane of mutant mice correlated with tympanic membrane retraction that was visible through the external auditory canal (EAC). Scale bar: 40um. C: At days 14-16 (n=5 for each genotype), some collagen (black asterisks) remains in both genotypes, but mutant mice also show a hyperplastic mucosa (red asterisk) with inflammation. The opening of the eustachian tube (ET) is indicated (arrowheads). Inset shows a polyp (red arrowhead) and numerous inflammatory cells (black arrow) found in some mutant mice.

Copyright

This image is from Depreux FF, J Clin Invest 2008 Feb;118(2):651-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:131873

Associated Alleles

Symbol	Name
Eya4^tm1Jse	EYA transcriptional coactivator and phosphatase 4; targeted mutation 1, Jonathan G Seidman

Associated Genotypes

Allelic Composition	Genetic Background
Eya4^tm1Jse/Eya4^tm1Jse	involves: 129S6/SvEvTac * CBA/J