Phenotype Image Detail

Image

Caption

Necropsies showing outflow tract defects in Dnah5^hlb612/Dnah5^hlb612 mice. A: D-malposition of great vessels is shown with levocardia with anterior and rightward aorta (Ao) relative to the poulmonary artery (PA). Episcopic flourescence image capture (EFIC) analysis showed that this heart was D-looped with dextro-transposition of great arteries (D-TGA). B: Dextrocardia with anterior and leftward aorta indicating L-malposition of great vessels. EFIC showed this was a D-looped heart with levo-transposition of great arteries (L-TGA). C: Mesocardia with parallel great vessels and right-sided aorta, i.e,. D-malposition. EFIC showed that this heart was D-looped with D-TGA. D: Dextrocardia with parallel great vessels and left-sided aorta, i.e., L-malposition. EFIC showed that this heart was D-looped with double outlet right ventricle (DORV). Scale bar: 1mm

Copyright

This image is from Tan SY, J Clin Invest 2007 Dec;117(12):3742-52 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130755

Associated Alleles

Symbol	Name
Dnah5^hlb612	dynein, axonemal, heavy chain 5; heart, lung and blood 612

Associated Genotypes

Allelic Composition	Genetic Background
Dnah5^hlb612/Dnah5^hlb612	involves: C57BL/6J