Phenotype Image Detail

Image

Caption

A: Time course of TUNEL staining in lumbar dorsal root ganglias (DRGs) of wild type or Ndn^tm1.1Mus/Ndn⁺ (Ndn KO) mice. Shown are the box-plots describing the number of TUNEL positive cells for lumbar DRGs; statistical comparisons were made using the Mann-Whitney test; asterisks show differences that are statistically significant (*, p<0.05). B: Double immunoflourescence labelling for TUNEL (in red) and Neurofilament (in green) in a lumbar ganglion of an E12.5 mutant embryo. In this figure, one immunopositive-cell for Neurofilament in the field whose nuclei are labelled by the apoptosis detection method (arrow). C: Double-labelling for TUNEL (in red) and BrdU (in green) after 2 hr injection; co-labelling was never observed, indicating that precursors are not dying in the Ndn^tm1.1Mus/Ndn⁺ mice. Scale bar: 10um (B and C).

Copyright

This image is from Andrieu D, BMC Dev Biol 2006;6():56, an open-access article, licensee BioMed Central Ltd. J:119656

Associated Alleles

Symbol	Name
Ndn^tm1.1Mus	necdin, MAGE family member; targeted mutation 1.1, Francoise Muscatelli

Associated Genotypes

Allelic Composition	Genetic Background
Ndn^tm1.1Mus/Ndn^+	B6.129S2-Ndn^tm1.1Mus