Phenotype Image Detail

Image

Caption

C and D: Parvalbumin immunostaining on transverse section at E17.5 showing a decrease of proprioceptive afferences in the mutant Ndn^tm1.1Mus/Ndn⁺(D) spinal cord compared to wild type (C). E: Representative scheme of defect observed in (C) and (D). F-I: CGRP immunostaining on coronal section, at adulthood, showing a similar innervation pattern of TrkA fibers in the hindpaw pad (F-G) around a hair follicle or (H-I) in the epidermis under nail of the second toe in mutant (G-I) or wild type (F-H) mice. We notice a decrease in the number of fibers in the mutant mouse. Abbreviations: ab, anterior bud; Ep, epidermis; HF, hair follicle; lcb, lateral cutaneous branch. Scale bar: A, 500um; C,D and F-I, 500um.

Copyright

This image is from Andrieu D, BMC Dev Biol 2006;6():56, an open-access article, licensee BioMed Central Ltd. J:119656

Associated Alleles

Symbol	Name
Ndn^tm1.1Mus	necdin, MAGE family member; targeted mutation 1.1, Francoise Muscatelli

Associated Genotypes

Allelic Composition	Genetic Background
Ndn^tm1.1Mus/Ndn^+	B6.129S2-Ndn^tm1.1Mus