Phenotype Image Detail

Image

Caption

Histopathology in the kidney of Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Mrl/Nos2^tm1Mrl Nos3^tm1Plh/Nos3^tm1Plh (n/i/eNOS^-/^-) and wild type (C57BL/6) mice. A: Renal tubular apoptosis (arrows) and regeneration (increased cell number) in mutant mice. H&E, hematoxylin and eosin staining. B: Renal glomerulosclerosis (hyalinization, pink color) in mutant mice. PAS, periodic acid-Schiff staining. C: Renal glomerular thrombi (arrows, dark blue) in mutant mice. PTAH, phosphotungstic acid-hematoxylin staining. Scale bars: 10um.

Copyright

This image is from Morishita T, Proc Natl Acad Sci U S A 2005 Jul 26;102(30):10616-21. Copyright 2005 National Academy of Sciences, U.S.A. J:100308

Associated Alleles

Symbol	Name
Nos1^tm1Plh	nitric oxide synthase 1, neuronal; targeted mutation 1, Paul L Huang
Nos2^tm1Mrl	nitric oxide synthase 2, inducible; targeted mutation 1, Merck Research Laboratory
Nos3^tm1Plh	nitric oxide synthase 3, endothelial cell; targeted mutation 1, Paul L Huang

Associated Genotypes

Allelic Composition	Genetic Background
Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Mrl/Nos2^tm1Mrl Nos3^tm1Plh/Nos3^tm1Plh	involves: 129S4/SvJae * 129S7/SvEvBrd