Phenotype Image Detail

Image

Caption

A: Morphology of Purkinje cells from Prex1^tm1Hcew/Prex1^tm1Hcew Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg} (DKo) pups. Cerebellar slices from 8-day-old double mutant and wild type (WT) mice, fixed, permeabilized, and stained for Calbindin (red) and with Hoechst (blue). Photos are representative of three slices per genotype. B: Morphology of Purkinje cells from cerebellar slices of 3-month-old double mutant and wild type mice. Photos are representative of three slices per genotype. Scale bars: A, 20um; B, 10um.

Copyright

This image is from Donald S, Proc Natl Acad Sci U S A 2008 Mar 18;105(11):4483-8. Copyright 2008 National Academy of Sciences, U.S.A. J:133335

Associated Alleles

Symbol	Name
Prex1^tm1Hcew	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; targeted mutation 1, Heidi C E Welch
Prex2^Gt(RRD186)Byg	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; gene trap RRD186, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Prex1^tm1Hcew/Prex1^tm1Hcew Prex2^Gt(RRD186)Byg/Prex2^Gt(RRD186)Byg	involves: 129P2/OlaHsd * C57BL/6