Phenotype Image Detail

Image

Caption

C: Foxp2^tm1Momo/Foxp2^tm1Momo mice (Homo, right) at P10 are about 30% smaller and Foxp2^tm1Momo/Foxp2⁺ mice (center) are about 10-15% smaller than wild type (left) mice. D: Brains of wild type (left), heterozygous (center), and homozygous mutant (right) mice at P10. Arrows indicate the cerebella. The size of the homozygous mutant cerebellum is smaller than the wild type and heterozygous ones. E: Hematoxylin and eosin stainng of the cerebella at P4 and P19. The development of folia of the homozygous mutant cerebellum was morphologically immature with less folia that were incompletely folded.

Copyright

This image is from Fujita E, Proc Natl Acad Sci U S A 2008 Feb 26;105(8):3117-22. Copyright 2008 National Academy of Sciences, U.S.A. J:132813

Associated Alleles

Symbol	Name
Foxp2^tm1Momo	forkhead box P2; targeted mutation 1, Takashi Momoi

Associated Genotypes

Allelic Composition	Genetic Background
Foxp2^tm1Momo/Foxp2^tm1Momo	involves: 129S6/SvEvTac * C57BL/6
Foxp2^tm1Momo/Foxp2^+	involves: 129S6/SvEvTac * C57BL/6