Phenotype Image Detail

Image

Caption

Typical patterns of cardiovascular abnormalities in Edn1^tm1Utj/Edn1^tm1Utj mice at 18.5 dpc. Normal control hearts and great vessels of wild type fetuses (A and D) and those of mAb-treated mutant fetuses (B-F). A: Normal heart and great vessels of a wild type fetus. Ao, aorta; PA, pulmonary artery; DA, ductus arteriosus; CCA, common carotid arteries; RSA, right subclavian artery. B: Deformed aortic arch with tubular hypoplasia (arrowhead) of an Edn1^tm1Utj/Edn1^tm1Utj homozygote. Arrows indicate extra arteries branching from the common carotid arteries. C: Aortic arch interruption and absent right subclavian artery of mutant fetus. Extra arteries are also seen (arrow). D: Appearance of a normal heart (left) and an homozygous mutant heart (right). The right ventricle is enlarged (arrow) in the mutant heart. E: Ventricular septal defect of a homozygous mutant. The defect (arrowhead) appears to be perimembranous and located in the outlet of the ventricle. The aorta overrides the crest of the ventricular septum. Inf, infundibulum; ST, septomarginal trabeculation of the right ventricle. F: Hematoxylin and eosin stained histological section of a mutant heart showing ventricular septal defect (arrowhead) and overriding aorta. LV, levt ventricle; RV, right ventricle.

Copyright

This image is from Kurihara Y, J Clin Invest 1995 Jul;96(1):293-300 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:26778

Associated Alleles

Symbol	Name
Edn1^tm1Utj	endothelin 1; targeted mutation 1, University of Tokyo

Associated Genotypes

Allelic Composition	Genetic Background
Edn1^tm1Utj/Edn1^tm1Utj	involves: 129X1/SvJ * ICR