Phenotype Image Detail

Image

Caption

(A and B) Light microscopy of Epon sections of liver stained with methylene blue/Azure II (x100) and (C and D) electron microscopy (x8,250) show numerous intracellular lipid droplets in the control pup (+/+), while this lipid appears instead in the sinusoidal space in the Lpl^tm1Bres/Lpl^tm1Bres (-/-) pup. (E) Electron microscopy of the mutant pup liver reveals extravasation of lipid (*) from the lipid-engorged sinusoids through endothelial fenestrations into the intercellular spaces (x16,500). Hp, hepatocyte; L, lipid; S, sinusoid; N, nucleus.

Copyright

This image is from Weinstock PH, J Clin Invest 1995 Dec;96(6):2555-68 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:30062

Associated Alleles

Symbol	Name
Lpl^tm1Bres	lipoprotein lipase; targeted mutation 1, Jan L Breslow

Associated Genotypes

Allelic Composition	Genetic Background
Lpl^tm1Bres/Lpl^tm1Bres	involves: 129S4/SvJae * C57BL/6J