Phenotype Image Detail

Image

Caption

Histopathology of mouse hearts. Hearts were fixed and mounted in paraffin blocks apex down. Adjacent step serial sections (5um) were taken every 75um. Representative transverse sections of hearts from Myh6^tm1Rbns/Myh6⁺ mice stained with hematoxylin and eosin (C and E) or trichrome (D and F) are shown. These sections were matched to wild type sections shown in panels A and B with regard to the position within the heart. The focal fibrotic lesions shown are characteristic of lesions seen in 5/8 heterozygous mouse hearts examined (arrows, D and F). No such lesions were seen in the ventricles of wild type mice (B). (A) shows a wild type section stained with hematoxylin and eosin. Although the hearts were fixed under identical conditions and were not significantly different in overall weight or measure, several heterozygous hearts showed a definite thickening of the left ventricular wall and septum. In a few cases, this extended to the right ventricular wall. lv, left ventricle; rv, right ventricle. x14.

Copyright

This image is from Jones WK, J Clin Invest 1996 Oct 15;98(8):1906-17 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:36089

Associated Alleles

Symbol	Name
Myh6^tm1Rbns	myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins

Associated Genotypes

Allelic Composition	Genetic Background
Myh6^tm1Rbns/Myh6^+	involves: 129P2/OlaHsd