Phenotype Image Detail

Image

Caption

High magnification light microscopy of mouse hearts. Hematoxylin and eosin stained sections from wild type (A) and Myh6^tm1Rbns/Myh6⁺ mouse ventricle (C). Notice the regular arrangement of myofibers in the wild type mouse, and the relative dissary noted in the heterozygous tissue. These regions of disarray near fibrotic lesions were seen in several heterozygotes. Magnification in A and C is x135. B and D x68 and x27, respectively. Photomicrographs of fibrotic lesions (blue stain) in the left ventriclar free wall (B) and septum (D) of a heart from a heterozygous mutant mouse.

Copyright

This image is from Jones WK, J Clin Invest 1996 Oct 15;98(8):1906-17 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:36089

Associated Alleles

Symbol	Name
Myh6^tm1Rbns	myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins

Associated Genotypes

Allelic Composition	Genetic Background
Myh6^tm1Rbns/Myh6^+	involves: 129P2/OlaHsd
Gt(ROSA)26Sor^tm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor^+ Tg(Prl-cre)#Salr/0	involves: 129S6/SvEvTac * C57BL/6 * SJL