Phenotype Image Detail

Image

Caption

Electron micrographs of longitudinal (A, C) and transverse (B, D) sections of ventricular cardiac myocyte cells from wild type (A, B) and Myh6^tm1Rbns/Myh6⁺ (C,D) mice. A: On longitudinal section, the sarcomeres from wild type myocardium have a regular organization with thick filaments extending between the I-bands (arrows indicate thick filaments that span the entire sarcomere, confirming that the section is cut transversely). C: The sarcomeres from the heterozygotes are shortened and the thick filaments extend from Z-band to Z-band (arrows, again indicating that the sections are cut transversely). The Z-bands are thicker and their centers more dense than their margins. Some areas along the sarcomeres have no thick filaments though thin filaments are present (arrowheads). On transverse sections from wild type cardiac muscle cells (B), the regular arrangement of thick and thin filaments is apparent. D: Transeverse sections from the heterozygote muscle have numerous areas depleted of thick filaments, seen as cleared areas (arrowheads). MI, mitochondria.

Copyright

This image is from Jones WK, J Clin Invest 1996 Oct 15;98(8):1906-17 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:36089

Associated Alleles

Symbol	Name
Myh6^tm1Rbns	myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jeffrey Robbins

Associated Genotypes

Allelic Composition	Genetic Background
Myh6^tm1Rbns/Myh6^+	involves: 129P2/OlaHsd