Phenotype Image Detail

Image

Caption

Histology of lung tissue from Thbs1^tm1Hyn/Thbs1^tm1Hyn and wild type mice. Representative sections are shown from mutant mice (B,D and F-H) and wild type mice (A,C and E). A and B: At 1 day of age, there is no difference in lung architecture or cytodifferentiation between mutant (B) and wild type (A) mice. Tissue sections were stained with hematoxylin and eosin. C and D: At 1 month of age, there are prominent neutrophilic infiltrates with some mononuclear cell infiltrates and early organization in mutant mice (D) but not in most wild type mice (C) (hematoxylin and eosin). E-H: At 4 months of age, lungs of wild type mice remain normal (E), but there is variable architectural disruption throughout the lungs of mutant mice (F-H) that is largely associated with scattered foci of acute and chronic organizing pneumonia (E and F, hematoxylin and eosin; G, trichrome stain; and H, elastin stain). Interstitial fibrous connective tissue was not observed with trichrome or elastin staining in wild type mice. Scale bar: 100um.

Copyright

This image is from Lawler J, J Clin Invest 1998 Mar 1;101(5):982-92 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:46182

Associated Alleles

Symbol	Name
Thbs1^tm1Hyn	thrombospondin 1; targeted mutation 1, Richard Hynes

Associated Genotypes

Allelic Composition	Genetic Background
Thbs1^tm1Hyn/Thbs1^tm1Hyn	either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)