Phenotype Image Detail

Image

Caption

Toluidine blue-stained sections of gastric glands in the corpus of adult wild type (A) and Slc9a2^tm1Ges/Slc9a2^tm1Ges (B), and from a 17 day old mutant mouse (C). A: Differentiated parietal cells (arrowheads) with characteristic mottled appearance and mature zymogenic cells (arrows) with numerous dense secretory granules are apparent in the normal gastric glands. B: In the adult mutant mice, mature zymogenic cells are absent, and the number of parietal cells are sharply reduced. Some parietal cells (arrowheads) contain large vacuoles and appear to be in various states of degeneration (the two lower cells indicated), whereas others (the two upper cells indicated) have abnormally light-staining cytoplasm. Note the structural changes characterized by expansion of the lamina propria, reduction in the volume of the gastric glands, and the presence of inflammatory cells. C: Fewer of the parietal cells (arrowheads) in the 17 day old mutant mice appear vacuolated compared with adult mutant mice, but they do have the abnormally light-staining cytoplasm Scale bar, 50um.

Copyright

This image is from Schultheis PJ, J Clin Invest 1998 Mar 15;101(6):1243-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:46545

Associated Alleles

Symbol	Name
Slc9a2^tm1Ges	solute carrier family 9 (sodium/hydrogen exchanger), member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc9a2^tm1Ges/Slc9a2^tm1Ges	involves: 129X1/SvJ * Black Swiss