Phenotype Image Detail

Image

Caption

Electron micrographs of parietal cells from six month old wild type (A) and Slc9a2^tm1Ges/Slc9a2^tm1Ges (B) mice. These cells have numerous mitochondria and extensive intracellular canalicular systems (c). The mutant parietal cell has many long microvilli and is virtually devoid of tubulovesicular membranes. Both features are characteristic of parietal cells that are secreting acid at a high rate. Scale bar, 5um.

Copyright

This image is from Schultheis PJ, J Clin Invest 1998 Mar 15;101(6):1243-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:46545

Associated Alleles

Symbol	Name
Slc9a2^tm1Ges	solute carrier family 9 (sodium/hydrogen exchanger), member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc9a2^tm1Ges/Slc9a2^tm1Ges	involves: 129X1/SvJ * Black Swiss