Phenotype Image Detail

Image

Caption

A: Testis of an 11 month old wild type mouse. B: Histological analysis of the testis shown in A. All the different stages of germ cells are present within the seminiferous tubules. C: Testis of an 11 month old Sox2^tm1Rlb/Sox2⁺ mouse showing reduced size and white opaque patches, indicative of sperm blockage. This was confirmed by histological analysis (D), where aberrant tubules were seen that contained very large numbers of mature sperm only, instead of a range of spermatogenic stages (arrow). The somatic cells also looked abnormal in these tubules. Scale bars: A and C, 1,260um; B, 55um; D, 42um.

Copyright

This image is from Kelberman D, J Clin Invest 2006 Sep;116(9):2442-55 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:114458

Associated Alleles

Symbol	Name
Sox2^tm1Rlb	SRY (sex determining region Y)-box 2; targeted mutation 1, Robin Lovell-Badge

Associated Genotypes

Allelic Composition	Genetic Background
Sox2^tm1Rlb/Sox2^+	involves: 129S/SvEv * MF1