Phenotype Image Detail

Image

Caption

A: Immunofluoresecence staining of mouse albumin in liver section of 5-month old Lipa^tm1Hodu/Lipa^tm1Hodu mouse. B and C: Immunohistochemical staining of macrophages specific antigen (F4/80) in liver section of mutant mice at 1 month (B) and 5 months (C). The arrows indicate the positive staining of F4/80, which is much weaker in 5-month mutant mouse liver owing to lipid storage and probably expansion of cellular membrane.

Copyright

This image is from Du H, J Lipid Res 2001 Apr;42(4):489-500 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:68812

Associated Alleles

Symbol	Name
Lipa^tm1Hodu	lysosomal acid lipase A; targeted mutation 1, Hong Du

Associated Genotypes

Allelic Composition	Genetic Background
Lipa^tm1Hodu/Lipa^tm1Hodu	involves: 129P2/OlaHsd * CF-1