Phenotype Image Detail

Image

Caption

Hematoxylin and eosin staining of paraffin-embedded sections of brown adipose tissue (BAT) and white adipose tissue (WAT) from wild type (+/+) and Lipa^tm1Hodu/Lipa^tm1Hodu (-/-) mice at 1.5 and 4 months of age. BAT in mutant mice at 1.5 months was similar to that of age-matched wild type mice. In comparison, WAT in mutant mice at 1.5 months was significantly diminished, and the adipocytes had considerable size heterogeneity compared with that of age-matched wild type mice. By 4 months of age, mutant mice had undetectable WAT. BAT in mutant mice at 4 months of age histologically resembled WAT, with increased lipid droplet size in the cells. Original amplification: 200x, except BAT from mutant at 4 months, at bottom: 400x.

Copyright

This image is from Du H, J Lipid Res 2001 Apr;42(4):489-500 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:68812

Associated Alleles

Symbol	Name
Lipa^tm1Hodu	lysosomal acid lipase A; targeted mutation 1, Hong Du

Associated Genotypes

Allelic Composition	Genetic Background
Lipa^tm1Hodu/Lipa^tm1Hodu	involves: 129P2/OlaHsd * CF-1