Phenotype Image Detail

Image

Caption

Itgb3^tm1Hyn/Itgb3^tm1Hyn mice display a variety of secondary phenotypes. Hematoxylin and eosin stained sections from wild type ( +/+, A,C,E and G) and from Itgb3^tm1Hyn/Itgb3^tm1Hyn (-/-, B,D,F and H) mice found in crisis. A and B: Gastrointestinal bleeding can be observed in the lamina propria between the stomach epithelium (E) and muscularis mucosae (M). C: White pulp (wp) and red pulp (rp) are clearly defined in wild type spleen. Splenomegaly in anemic mice with extramedullary erythropoiesis (D). Centrilobular necrosis of the mutant mouse liver (F) is a consequence of severe anemia resulting in lack of well-oxygenated blood reaching the centrilobular vein (clv). Glomerular nephritis and resultant tubular necrosis are also secondary to anemia (H). Notice the dialted proximal tubules (dpt), enlarged glomerulus (G), and proteinaceous deposits (P) in the tubules. Normal proximal tubules are denoted, pt. Scale bar: 70mm.

Copyright

This image is from Hodivala-Dilke KM, J Clin Invest 1999 Jan;103(2):229-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:52262

Associated Alleles

Symbol	Name
Itgb3^tm1Hyn	integrin beta 3; targeted mutation 1, Richard Hynes

Associated Genotypes

Allelic Composition	Genetic Background
Itgb3^tm1Hyn/Itgb3^tm1Hyn	involves: 129S2/SvPas * C57BL/6