Phenotype Image Detail

Image

Caption

(a) Inflammatory foci were scattered in the liver of a 2-month-old Gba1^tm1Rlp/Gba1^tm1Rlp mouse (arrows). (b) Higher magnification of an inflammatory area. Note the apoptotic hepatocyte in the inflammatory area (arrow). (c) Immunostaining with F4/80 antibody to visualize ramified Kupffer cells in wild-type liver sections. (d) In mutant liver, the F4/80-positive Kupffer cells were amoeboid and swollen. (e) TUNEL-positive, apoptotic nuclei (arrows) were distinguished in the inflammatory lesion of the mutant mouse. (f) TNF-alpha mRNA expression in the liver of mutant and wild type mice. *P <0.001. Results are means +/- SEM for four to seven mice each. Scale bars: 50um.

Copyright

This image is from Mizukami H, J Clin Invest 2002 May;109(9):1215-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76409

Associated Alleles

Symbol	Name
Gba1^tm1Rlp	glucosylceramidase beta 1; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Gba1^tm1Rlp/Gba1^tm1Rlp	involves: 129S4/SvJae * C57BL/6