Phenotype Image Detail

Image

Caption

Inset; liver section from a 7 month old Gba1^tm1Rlp/Gba1^tm1Rlp mutant mouse showing multinucleated macrophages (arrows) containing abundant brown granules in their cytoplasm. Bar = 50um. Main portion: Electron microscopy revealed that these cells contain lipofuscin granules (L) and abundant parallel and twisted tubular structures (arrows) in their cytoplasm. Bar = 0.25um.

Copyright

This image is from Mizukami H, J Clin Invest 2002 May;109(9):1215-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76409

Associated Alleles

Symbol	Name
Gba1^tm1Rlp	glucosylceramidase beta 1; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Gba1^tm1Rlp/Gba1^tm1Rlp	involves: 129S4/SvJae * C57BL/6