Phenotype Image Detail

Image

Caption

Comparative anatomy and histology are shown for wild type (+/+) and Sbf1^tm1Mlc/Sbf1^tm1Mlc (-/-) testes. (a and b) Male reproductive organs are shown for mice at 20 weeks of age. Mutant testis, but not epididymis, is considerably smaller compared with wild type (x2). (c and d) Sections of epididymis from 20 week old mice were stained with hematoxylin and eosin (x200). Note absence of spermatozoa in mutant epididymis. (e-n) Sections of wild type and mutant testes at different stages of spermatogenic development (specific time points indicated in the respective panels) were stained with hematoxylin and eosin (x200). Testes from mutant mice show extensive vacuolar degeneration that is apparent at day 17 and is followed by complete depletion of germ cells by 52 weeks.

Copyright

This image is from Firestein R, J Clin Invest 2002 May;109(9):1165-72 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76406

Associated Alleles

Symbol	Name
Sbf1^tm1Mlc	SET binding factor 1; targeted mutation 1, Michael L Cleary

Associated Genotypes

Allelic Composition	Genetic Background
Sbf1^tm1Mlc/Sbf1^tm1Mlc	involves: C57BL/6