Phenotype Image Detail

Image

Caption

A: Four month old Soat1^tm1Far/Soat1^tm1Far Apoe^tm1Unc/Apoe^tm1Unc (ACAT1-/- ApoE-/-) fed a chow diet. Note the diffuse hair loss and excoriations due to pruritic skin lesions. B-D: Hematoxylin and eosin stained sections of skin from 4 month old, chow fed Apoe^tm1Unc/Apoe^tm1Unc (B, x40), and double homozygous (C, x40; D, x100) mice. Marked thickening of skin was observed in double homozygous mice (C), with an intense inflammatory reaction disrupting the subcutaneous fat layer and muscularis carnosus. Severe fibrosis was present in the deeper layers of the skin. Higher magnification of the reticular dermis (D) revealed numerous cholesterol clefts and a pleomorphic inflammatory infiltrate that included multinucleated giant cells, neutrophils, mononuclear cells and plasma cells. E: Skin cholesterol content of 4 month old chow fed mice (n=2 in each group). F: Hematoxylin and eosin stained section of brain from double homozygous mouse fed a Western diet for 3 months. Note the free cholesterol crystal deposits and inflammatory infiltrate near the choroid plexus.

Copyright

This image is from Accad M, J Clin Invest 2000 Mar;105(6):711-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61147

Associated Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Soat1^tm1Far	sterol O-acyltransferase 1; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J