Phenotype Image Detail

Image

Caption

Severe xanthomatosis in Soat1^tm1Far/Soat1^tm1Far Ldlr^tm1Her/Ldlr^tm1Her (ACAT1-/-LDLR-/-) mice fed an atherogenic diet for 2 months. A: Appearance of double homozygous mutant mouse compared to Ldlr^tm1Her/Ldlr^tm1Her littermate control (ACAT1+/+LDLR-/-). The marked skin thickening gives the double homozygous mouse an obese appearance. B-D: In hematoxylin and eosin stained skin sections, no abnormalities were detected in littermate controls (B, x40); thickened skin and inflammation were present in double homozygous mice (C, x40; D, x100). The marked skin thickening in double homozygous mice (C and D) was associated with dermal edema and a pleomorphic inflammatory infiltrate with cholesterol clefts (D, thin arrows) and multinucleated giant cells (D, open arrows). E and F: Hematoxylin and eosin stained sections of brain of double homozygous mice demonstrating free cholesterol crystal deposits in the cerebellum (E, x10) and near the choroid plexus (F, x40).

Copyright

This image is from Accad M, J Clin Invest 2000 Mar;105(6):711-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61147

Associated Alleles

Symbol	Name
Ldlr^tm1Her	low density lipoprotein receptor; targeted mutation 1, Joachim Herz
Soat1^tm1Far	sterol O-acyltransferase 1; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Ldlr^tm1Her/Ldlr^tm1Her Soat1^tm1Far/Soat1^tm1Far	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J